fnctId=profInfo,fnctNo=751
About
Education
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1996Bachelor's Degree 제약학과, Seoul National University
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1998Master's Degree 약학과, Seoul National University
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2001Doctor's Degree 약학, Seoul National University
Career
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2001 ~ 2003예일대 Post-Doc.Fellow
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2003 ~ 2006서울대학교 선임연구원
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2006 ~ 2007인하대학교 연구교수
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2006 ~ 2007인하대학교 책임연구원
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2007 ~ 2011인하대학교 조교수
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2011 ~ 2012인하대학교 Associate Editor
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2011 ~ 2016인하대학교 부교수
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2012 ~ 2015인하대학교 INHA FELLOW PROFESSOR
Research interests
- New Drug Discovery for Cancer Therapy
- Biomarker for Cancer Diagnosis
Research
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Thesis펼치기
- Effect of CCl4-induced hepatic failure on the hepatobiliary transport of Organic Cations, 2001
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Journal Articles펼치기
- Potential role of ANGPTL4 in cancer progression, metastasis, and metabolism, BMB reports, Vol.57,No.8, 343~351, 2024
- Tumor stroma as a therapeutic target for pancreatic ductal adenocarcinoma, BIOMOLECULES & THERAPEUTICS, Vol.32,No.3, 281~290, 2024
- Acetyl-CoA synthetase 2 contributes to a better prognosis for liver cancer by switching acetate-glucose metabolism, EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.56, 721~733, 2024
- Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis, BIOMOLECULES & THERAPEUTICS, Vol.31,No.6, 599~610, 2023
- Multivalent Carbohydrate Nanocomposites for Tumor Microenvironment Remodeling to Enhance Antitumor Immunity, ACS NANO, Vol.17,No.12, 11567~11582, 2023
- Vactosertib, TGF-β receptor I inhibitor, augments the sensitization of the anti-cancer activity of gemcitabine in pancreatic cancer, BIOMEDICINE & PHARMACOTHERAPY, Vol.12, 114716, 2023
- Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, Vol.29,No.9, 2663~2677, 2023
- A combination of BR101801 and venetoclax enhances antitumor effect in DLBCL cells via c-Myc/Bcl-2/Mcl-1 triple targeting, AMERICAN JOURNAL OF CANCER RESEARCH, Vol.13,No.2, 452~463, 2023
- Argonaute 2 Restores Erectile Function by Enhancing Angiogenesis and Reducing Reactive Oxygen Species Production in Streptozotocin (STZ)-Induced Type-1 Diabetic Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.24,No.3, 2935, 2023
- IGFBP5 antisense and short hairpin RNA (shRNA) constructs improve erectile function by inducing cavernosum angiogenesis in diabetic mice, ANDROLOGY, Vol.11,No.2, 358~371, 2023
- Chemical Biopsy for GNMT as Noninvasive and Tumorigenesis-Relevant Diagnosis of Liver Cancer, ANALYTICAL CHEMISTRY, Vol.95,No.2, 1184~1192, 2023
- Heat Shock Protein 70 in Penile Neurovascular Regeneration Requires Cystathionine Gamma-Lyase, World Journal of Mens Health, Vol.40,No.4, 580~599, 2022
- A novel DDR1 inhibitor enhances the anticancer activity of gemcitabine in pancreatic cancer, AMERICAN JOURNAL OF CANCER RESEARCH, Vol.12,No.9, 4326~4342, 2022
- Discovery of a novel NUAK1 inhibitor against pancreatic cancer, BIOMEDICINE & PHARMACOTHERAPY, Vol.152, 2022
- Lidocaine enhances the efficacy of palbociclib in triple-negative breast cancer, AMERICAN JOURNAL OF CANCER RESEARCH, Vol.12,No.7, 3083~3098, 2022
- Pericyte-derived extracellular vesicle-mimetic nanovesicles ameliorate erectile dysfunction via lipocalin 2 in diabetic mice, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, Vol.18,No.9, 3653~3667, 2022
- Combination Therapy of the Active KRAS-Targeting Antibody inRas37 and a PI3K Inhibitor in Pancreatic Cancer, BIOMOLECULES & THERAPEUTICS, Vol.30,No.3, 274~283, 2022
- Comparative analysis of mesenchymal stem cells cultivated in serum free media, Scientific Reports, Vol.12,No.1, 2022
- HS-173, a novel PI3K inhibitor enhances radiosensitivity of breast cancer cells, INTERNATIONAL JOURNAL OF RADIATION RESEARCH, Vol.20,No.2, 347~352, 2022
- Pericyte derived extracellular vesicles mimetic nanovesicles improves peripheral nerve regeneration in mouse models of sciatic nerve transection, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol.49, 18, 2022
- A Serum Marker for Early Pancreatic Cancer With a Possible Link to Diabetes, JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol.114,No.2, 228~234, 2022
- ANGPTL4 accelerates KRAS(G12D)-Induced acinar to ductal metaplasia and pancreatic carcinogenesis, CANCER LETTERS, Vol.519, 185~198, 2021
- Emerging roles of PHLPP phosphatases in metabolism, BMB reports, Vol.54,No.9, 451~457, 2021
- Intracellular KRAS-specific antibody enhances the anti-tumor efficacy of gemcitabine in pancreatic cancer by inducing endosomal escape, CANCER LETTERS, Vol.507, 97~111, 2021
- Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury, JOURNAL OF SEXUAL MEDICINE, Vol.18,No.1, 17~28, 2021
- Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice, Scientific Reports, Vol.11,No.1, 2021
- Development and Therapeutic Potential of NUAKs Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, Vol.64,No.1, 2~25, 2021
- Neutralizing antibody to proNGF rescues erectile function by regulating the expression of neurotrophic and angiogenic factors in a mouse model of cavernous nerve injury, ANDROLOGY, Vol.9,No.1, 329~341, 2021
- MEK blockade overcomes the limited activity of palbociclib in head and neck cancer, TRANSLATIONAL ONCOLOGY, Vol.13,No.11, 2020
- Selonsertib Inhibits Liver Fibrosis via Downregulation of ASK1/MAPK Pathway of Hepatic Stellate Cells, BIOMOLECULES & THERAPEUTICS, Vol.28,No.6, 527~536, 2020
- Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity, REDOX BIOLOGY, Vol.37, 2020
- Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse, ANDROLOGY, Vol.8,No.5, 1387~1397, 2020
- ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a, EMBO MOLECULAR MEDICINE, Vol.12,No.8, 2020
- Artemisiae Iwayomogii Herba Inhibits Growth, Motility, and the PI3K/AKT/mTOR Signaling Pathway in Hepatocellular Carcinoma Cells, PLANTA MEDICA, Vol.86,No.10, 717~727, 2020
- HS-146, a novel phosphoinositide 3-kinase alpha inhibitor, induces the apoptosis and inhibits the metastatic ability of human breast cancer cells, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.56,No.6, 1509~1520, 2020
- SB365 induces apoptosis and suppresses proliferation of glioblastoma cells, INDIAN JOURNAL OF PHARMACOLOGY, Vol.52,No.2, 102~107, 2020
- PBT-6, a Novel PI3KC2 gamma Inhibitor in Rheumatoid Arthritis, BIOMOLECULES & THERAPEUTICS, Vol.28,No.2, 172~183, 2020
- Apoptotic Effects of Xanthium strumarium via PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma, EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, Vol.2019, 2019
- Systemic and Local Metabolic Alterations in Sleep-Deprivation-Induced Stress: A Multiplatform Mass-Spectrometry-Based Lipidomics and Metabolomics Approach, JOURNAL OF PROTEOME RESEARCH, Vol.18,No.9, 3295~3304, 2019
- Steroidomics for the Prevention, Assessment, and Management of Cancers: A Systematic Review and Functional Analysis, METABOLITES, Vol.9,No.10, 2019
- Spheroid-Induced Epithelial-Mesenchymal Transition Provokes Global Alterations of Breast Cancer Lipidome: A Multi-Layered Omics Analysis, FRONTIERS IN ONCOLOGY, Vol.9, 2019
- HS-173 as a novel inducer of RIP3-dependent necroptosis in lung cancer, CANCER LETTERS, Vol.444, 94~104, 2019
- Metabolomics Approach Based on Multivariate Techniques for Blood Transfusion Reactions, SCIENTIFIC REPORTS, Vol.9, 2019
- An Integrative Data Mining and Omics-Based Translational Model for the Identification and Validation of Oncogenic Biomarkers of Pancreatic Cancer, CANCERS, Vol.11,No.2, 2019
- A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death, Journal of Ginseng Research, Vol.43,No.1, 86~94, 2019
- Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties, MOLECULES, Vol.23,No.10, 2018
- Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study, BIOORGANIC & MEDICINAL CHEMISTRY, Vol.26,No.21, 5596~5611, 2018
- NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase alpha and its implication in breast cancer cell proliferation, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, Vol.22,No.9, 4117~4129, 2018
- HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis, Experimental and Molecular Medicine, Vol.50, 2018
- KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer, CANCER LETTERS, Vol.438, 174~186, 2018
- A systematic review on metabolomics-based diagnostic biomarker discovery and validation in pancreatic cancer, METABOLOMICS, Vol.14,No.8, 2018
- An ethyl acetate fraction of Artemisia capillaris (ACE-63) induced apoptosis and anti-angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma, PHYTOTHERAPY RESEARCH, Vol.32,No.10, 2034~2046, 2018
- A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer, CANCER LETTERS, Vol.426, 25~36, 2018
- Neutrophil elastase in cervical fluid in women with short cervical length, TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, Vol.57,No.3, 407~410, 2018
- Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-beta/STAT3 Pathway, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, Vol.47,No.5, 1751~1768, 2018
- Artemisia Capillaris leaves inhibit cell proliferation and induce apoptosis in hepatocellular carcinoma, BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, Vol.18, 2018
- Artemisia capillaris extract AC68 induces apoptosis of hepatocellular carcinoma by blocking the PI3K/AKT pathway, BIOMEDICINE & PHARMACOTHERAPY, Vol.98, 134~141, 2018
- Radiosensitization of the PI3K inhibitor HS-173 through reduction of DNA damage repair in pancreatic cancer, ONCOTARGET, Vol.8,No.68, 112893~112906, 2017
- Systematic assessment of cervical cancer initiation and progression uncovers genetic panels for deep learning-based early diagnosis and proposes novel diagnostic and prognostic biomarkers, ONCOTARGET, Vol.8,No.65, 109436~109456, 2017
- Identification of 4-Phenoxyquinoline Based Inhibitors for L1196M Mutant of Anaplastic Lymphoma Kinase by Structure-Based Design, JOURNAL OF MEDICINAL CHEMISTRY, Vol.60,No.22, 9205~9221, 2017
- Tumor vessel normalization by the PI3K inhibitor HS-173 enhances drug delivery, CANCER LETTERS, Vol.403, 339~353, 2017
- Co-targeting of EGF receptor and neuropilin-1 overcomes cetuximab resistance in pancreatic ductal adenocarcinoma with integrin beta 1-drivenSrc-Akt bypass signaling, ONCOGENE, Vol.36,No.18, 2543~2552, 2017
- Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats, EXPERIMENTAL AND THERAPEUTIC MEDICINE, Vol.13,No.5, 2043~2049, 2017
- Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer, CANCER LETTERS, Vol.396, 155~166, 2017
- NQO1 inhibits proteasome-mediated degradation of HIF-1 alpha, NATURE COMMUNICATIONS, Vol.7, 13593, 2016
- Optimization and biological evaluation of aminopyrimidine-based I kappa B kinase beta inhibitors with potent anti-inflammatory effects, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, Vol.123, 544~556, 2016
- HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer, ONCOTARGET, Vol.7,No.47, 78029~78047, 2016
- The effect of neutral-surface iron oxide nanopar-ticles on cellular uptake and signaling pathways, INTERNATIONAL JOURNAL OF NANOMEDICINE, Vol.11, 4595~4607, 2016
- Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1 alpha and causes cancer cell death under hypoxia, Scientific Reports, Vol.6, 2016
- Penile erection induces angiogenic, survival, and antifibrotic signals: molecular events associated with penile erection induced by cavernous nerve stimulation in mice, INTERNATIONAL JOURNAL OF UROLOGY, Vol.23,No.7, 614~622, 2016
- Aminoacyl-tRNA synthetase interacting multi-functional protein 1 attenuates liver fibrosis by inhibiting TGF beta signaling, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.48,No.2, 747~755, 2016
- Centella asiatica Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats, Journal of Medicinal Food, Vol.19,No.1, 38~46, 2016
- Targeting L-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics, EXPERT OPINION ON THERAPEUTIC TARGETS, Vol.19,No.10, 1319~1337, 2015
- Effect of adipose-derived stem cell-conditioned medium on the proliferation and migration of B16 melanoma cells, ONCOLOGY LETTERS, Vol.10, 730~736, 2015
- A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor b Subunit, Glycoprotein 130, JOURNAL OF IMMUNOLOGY, Vol.195, 237~245, 2015
- Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo, Journal of Korean Medical Science, Vol.30,No.7, 979~987, 2015
- CD-200 induces apoptosis and inhibits Bcr-Abl signaling in imatinib-resistant chronic myeloid leukemia with T315I mutation, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.47, 253~261, 2015
- Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics, CELL RESEARCH, Vol.25, 707~725, 2015
- Therapeutic effect of human clonal bone marrow-derived mesenchymal stem cells in severe acute pancreatitis, ARCHIVES OF PHARMACAL RESEARCH, Vol.38,No.5, 742~751, 2015
- HS-543 Induces Apoptosis of Imatinib-Resistant Chronic Myelogenous Leukemia with T315I Mutation, ONCOTARGET, Vol.6,No.3, 1507~1518, 2015
- Effects of environmental temperature change on mercury absorption in aquatic organisms with respect to climate warming, JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, Vol.77, 1477~1490, 2014
- SB365, Pulsatilla saponin D, suppresses the growth of gefitinib-resistant NSCLC cells with Met amplification, ONCOLOGY REPORTS, Vol.32, 2612~2618, 2014
- HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy, ONCOTARGET, Vol.5,No.20, 10180~10197, 2014
- AAPE proliposomes for topical atopic dermatitis treatment, JOURNAL OF MICROENCAPSULATION, Vol.31,No.8, 768~773, 2014
- Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer, ONCOTARGET, Vol.5,No.19, 9150~9168, 2014
- Anticancer Activity of HS-527, a Novel Inhibitor Targeting PI3-Kinase in Human Pancreatic Cancer Cells, CANCER LETTERS, Vol.53,No.1, 68~77, 2014
- Development and Biological Evaluation of Potent and Selective c-KITD816V Inhibitors, JOURNAL OF MEDICINAL CHEMISTRY, Vol.57,No.15, 6428~6443, 2014
- HS-104, a PI3K inhibitor, enhances anticancer efficacy of gemcitabine in pancreatic cancer, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.45, 311~321, 2014
- 20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin, ONCOTARGET, Vol.5,No.12, 4438~4451, 2014
- HS-438, a new inhibitor of Imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia, CANCER LETTERS, Vol.348, 50~60, 2014
- Targeted delivery system of nanobiomaterials in anticancer therapy: form cells to clinics, BioMed Research International, Vol.2014, 814208, 2014
- Combined application of dispersive liquid뻦iquid microextraction based on the solidification of floating organic droplets and charged aerosol detection for the simple and sensitive quantification of macrolide antibiotics in human urine, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol.86, 204~213, 2013
- HS-173, a Novel PI3K Inhibitor, Attenuates the Activation of Hepatic Stellate Cells in Liver Fibrosis, Scientific Reports, Vol.3, 3470, 2013
- Induction of apoptosis and suppression of angiogenesis of hepatocellular carcinoma by HS-159, a novel phosphatidylinositol 3-kinase inhibitor, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.43, 201~209, 2013
- A novel PI3K inhibitor alleviates fibrotic responses in fibroblasts derived from Peyronie's plaques, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.42,No.6, 2001~2008, 2013
- SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells, ONCOLOGY REPORTS, Vol.30, 801~808, 2013
- Discovery of new benzothiazole-based inhibitors of breakpoint cluster region-Abelson kinase including the T315I mutant, JOURNAL OF MEDICINAL CHEMISTRY, Vol.26,No.9, 3531~3545, 2013
- SB365, Pulsatilla saponin D targets c-Met and exerts antiangiogenic and anti-tumor activities, CARCINOGENESIS, 2013
- A novel imidazopyridine PI3K inhibitor with anticancer activity in non-small cell lung cancer cells, ONCOLOGY REPORTS, Vol.30, 863~869, 2013
- A formulated red ginseng extract upregulates CHOP and increases TRAIL-mediated cytotoxicity in human hepatocellular carcinoma cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 2013
- Anti-cancer effect of HS-345, a new tropomyosin-related kinase A inhibitor, on human pancreatic cancer, CANCER LETTERS, 2013
- KRC-327, a Selective Novel Inhibitor of c-Met Receptor Tyrosine Kinase with Anticancer Activity, CANCER LETTERS, Vol.331,No.2, 158~166, 2013
- KRC-408, a Novel c-Met Inhibitor, Suppresses Cell Proliferation and Angiogenesis of Gastric Cancer, CANCER LETTERS, Vol.332,No.1, 74~82, 2013
- Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells, CANCER LETTERS, Vol.328, 152~159, 2013
- Sensitization of TRAIL-Induced Cell Death by 20(S)-Ginsenoside Rg3 via CHOP-Mediated DR5 Upregulation in Human Hepatocellular Carcinoma Cells, MOLECULAR CANCER THERAPEUTICS, Vol.12,No.3, 274~285, 2013
- A novel imidazopyridine derivative, HS-106, induces apoptosis of breast cancer cells and represses angiogenesis by targeting the PI3K/mTOR pathway, CANCER LETTERS, Vol.329,No.1, 59~67, 2013
- IPD-196, a novel phosphatidylinositol 3-kinase inhibitor with potent anticancer activity against hepatocellular carcinoma, CANCER LETTERS, Vol.329,No.1, 99~108, 2013
- Investigation of metabolite alteration in dimethylnitrosamine-induced liver fibrosis by GC-MS, BIOANALYSIS, Vol.5,No.1, 41~51, 2013
- SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway, FOOD CHEMISTRY, Vol.136, 26~33, 2013
- Suppression of tumor proliferation and angiogenesis of hepatocellular carcinoma by HS-104, a novel phosphoinositide 3-kinase inhibitor, CANCER LETTERS, Vol.328, 176~187, 2013
- HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis, CANCER LETTERS, Vol.328, 152~159, 2013
- Antitumor activity of Pulsatilla koreana extract in anaplastic thyroid cancer via apoptosis and anti-angiogenesis, MOLECULAR MEDICINE REPORTS, Vol.7, 26~30, 2013
- Anticancer effects of KI-10F: A novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.41,No.5, 1715~1722, 2012
- SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway, CANCER SCIENCE, Vol.103,No.11, 1929~1937, 2012
- In vitro and in vivo evaluation of N,N,N-trimethylphytosphingosine-iodide (TMP) in liposomes for the treatment of angiogenesis and metastasis, INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.434,1-2, 191~198, 2012
- Comparison of oxidized porous silicon with bare porous silicon as a photothermal agent for cancer cell destruction based on in vitro cell test results, LASERS IN MEDICAL SCIENCE, Vol.27,No.5, 1001~1008, 2012
- Protective Effect of Fucoidan against Acetaminophen-Induced Liver Injury, ARCHIVES OF PHARMACAL RESEARCH, Vol.35,No.6, 1099~1105, 2012
- In-vitro cell tests using doxorubicin-loaded polymeric TiO2 nanotubes used for cancer photothermotherapy, ANTI-CANCER DRUGS, Vol.23,No.5, 553~560, 2012
- Design, Synthesis, and Evaluation of 3,5-Disubstituted 7-Azaindoles as Trk Inhibitors with Anticancer and Antiangiogenic Activities, JOURNAL OF MEDICINAL CHEMISTRY, Vol.55,No.11, 5337~5349, 2012
- A novel imidazopyridine analogue as a phosphatidylinositol 3-kinase inhibitor against human breast cancer, CANCER LETTERS, Vol.318,No.1, 68~75, 2012
- The effect of HS-111, a novel thiazolamine derivative, on apoptosis and angiogenesis of hepatocellular carcinoma cells, ARCHIVES OF PHARMACAL RESEARCH, Vol.35,No.4, 747~754, 2012
- Progress in cancer therapy targeting c-Met signaling pathway, ARCHIVES OF PHARMACAL RESEARCH, Vol.35,No.4, 595~604, 2012
- HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway, CANCER LETTERS, Vol.316,No.2, 187~195, 2012
- Apoptotic and anti-angiogenic effects of Pulsatilla koreana extract on hepatocellular carcinoma, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol.40,No.2, 452~460, 2012
- In-vivo cancer cell destruction using porous silicon nanoparticles, ANTI-CANCER DRUGS, Vol.22,No.10, 971~977, 2011
- 소화기질환에서의 줄기세포 치료에 대한 전임상 연구, The Korean Journal of Gastroenterology, Vol.58,No.3, 133~138, 2011
- Anti-cancer effects of a novel compound HS-113 on cell growth, apoptosis, and angiogenesis in human hepatocellular carcinoma cells, CANCER LETTERS, Vol.306,No.2, 190~196, 2011
- Suppression by Fucoidan of Liver Fibrogenesis via the TGF-beta/Smad Pathway in Protecting against Oxidative Stress, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol.75,No.5, 833~840, 2011
- Porous silicon nanoparticles for cancer photothermotherapy, NANOSCALE RESEARCH LETTERS, Vol.6, 2011
- Design and Synthesis of Imidazopyridine Analogues as Inhibitors of Phosphoinositide 3-Kinase Signaling and Angiogenesis, JOURNAL OF MEDICINAL CHEMISTRY, Vol.54,No.7, 2455~2466, 2011
- Fluorescent phosphoinositide 3-kinase inhibitors suitable for monitoring of intracellular distribution, BIOORGANIC & MEDICINAL CHEMISTRY, Vol.19,No.8, 2508~2516, 2011
- Human Bone Marrow-Derived Clonal Mesenchymal Stem Cells Inhibit Inflammation and Reduce Acute Pancreatitis in Rats, GASTROENTEROLOGY, Vol.140,No.3, 998~1008, 2011
- Predicting idiopathic toxicity of cisplatin by a pharmacometabonomic approach, KIDNEY INTERNATIONAL, Vol.79,No.5, 529~537, 2011
- Poloxamer/Cyclodextrin/Chitosan-Based Thermoreversible Gel for Intranasal Delivery of Fexofenadine Hydrochloride, JOURNAL OF PHARMACEUTICAL SCIENCES, Vol.100,No.2, 681~691, 2011
- An Effective Assessment of Simvastatin-Induced Toxicity with NMR-Based Metabonomics Approach, PLOS ONE, Vol.6,No.2, 2011
- The use of low molecular weight heparin-pluronic nanogels to impede liver fibrosis by inhibition the TGF-beta/Smad signaling pathway, BIOMATERIALS, Vol.32,No.5, 1438~1445, 2011
- Identification of Urinary Biomarkers Related to Cisplatin-Induced Acute Renal Toxicity Using NMR-Based Metabolomics, BIOMOLECULES & THERAPEUTICS, Vol.19,No.1, 38~44, 2011
- Discovery of new azaindole-based PI3K alpha inhibitors: Apoptotic and antiangiogenic effect on cancer cells, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.20, 7212~7215, 2010
- Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer, ONCOLOGY REPORTS, Vol.24, 957~963, 2010
- The Protective Effect of Resveratrol on Dimethylnitrosamine-Induced Liver Fibrosis in Rats, ARCHIVES OF PHARMACAL RESEARCH, Vol.33, 601~609, 2010
- Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats, JOURNAL OF PINEAL RESEARCH, Vol.48, 239~250, 2010
- Development of New Fluorescent Xanthines as Kinase Inhibitors, ORGANIC LETTERS, Vol.12, 1212~1215, 2010
- Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer, BIOMATERIALS, Vol.31, 4995~5006, 2010
- Effect of steam treatment on soluble phenolic content and antioxidant activity of the Chaga mushroom (Inonotus obliquus), FOOD CHEMISTRY, Vol.119, 619~625, 2010
- Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-κB during prevention of oxidative liver injury in a dimethylnitrosamine model, JOURNAL OF PINEAL RESEARCH, Vol.47, 173~183, 2009
- Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.24, 1445~1450, 2009
- Proteomic approach to the cytotoxicity of 5-FU in colon cancer cells, YAKHAK HOEJI, Vol.53, 145~150, 2009
- IN-1130, a Novel Transforming Growth Factor-β Type I Receptor Kinase (Activin Receptor-like Kinase 5) Inhibitor, Promotes Regression of Fibrotic Plaque and Corrects Penile Curvature in a Rat Model of Peyronie's Disease, JOURNAL OF SEXUAL MEDICINE, 1284~1296, 2009
- Protective effect of morin on dimethylnitrosamine (DMN)-induced hepatic fibrosis in rats, DIGESTIVE DISEASES AND SCIENCES, Vol.54, 782~788, 2009
- Characterization of increased phenolic compounds from fermented Bokbunja (Rubus coreanus Miq.) and related antioxidant activity, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol.49, 820~827, 2009
- Proteome changes related to the anti-cancer activity of HT29 cells by the treatment of ginsenoside Rd, PHARMAZIE, Vol.64, 242~247, 2009
- Proteomic analysis of the anti-cancer effect of 20S-ginsenosides Rg(3) in human colon cancer cell lines, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol.73, 811~816, 2009
- Antioxidant and skin whitening effect of aqueous extracts of Salicornia herbacea, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol.73, 552~556, 2009
- Reduced Antidiabetic Effect of Metformin and Down-regulation of Hepatic Oct1 in Rats with Ethynylestradiol-Induced Cholestasis, PHARMACEUTICAL RESEARCH, Vol.26,No.3, 549~559, 2009
- Anti-Cancer Effect of Betulin on a Human Lung Cancer, PLANTA MEDICA, Vol.75, 127~131, 2009
- Rapid and Simultaneous Determination of Ginsenosides Rb1, Rb2, Rc and Re in Korean Red Ginseng Extract by HPLC using Mass/Mass Spectrometry and UV Detection, Journal of Ginseng Research, Vol.32,No.4, 390~396, 2008
- Enhancement in photoluminescence of porous silicon deposited by sputtering an ultrathin silver film, JOURNAL OF THE KOREAN PHYSICAL SOCIETY, Vol.53,No.5, 2562~2567, 2008
- Synthesis of Very Straight Bismuth Oxide Nanowires by Using Thermal Evaporation of Bismuth Powders, JOURNAL OF THE KOREAN PHYSICAL SOCIETY, Vol.53, 1965~1970, 2008
- Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons, BRAIN RESEARCH, Vol.1229, 147~154, 2008
- Morin protects acute liver damage by carbon tetrachloride (CCl(4)) in rat, ARCHIVES OF PHARMACAL RESEARCH, Vol.31,No.9, 1160~1165, 2008
- Porous silicon as an agent for cancer thermotherapy based on near-infrared light irradiation, JOURNAL OF MATERIALS CHEMISTRY, Vol.18, 4790~4795, 2008
- Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis, ONCOLOGY REPORTS, Vol.20, 129~134, 2008
- Enhanced systemic availability of methotrexate in the presence of morin in rats, BIOPHARMACEUTICS & DRUG DISPOSITION, Vol.29, 189~193, 2008
- Interaction characteristics of flavonoids with human organic anion transporter 1 (hOAT1) and 3 (hOAT3), PHARMACOLOGICAL RESEARCH, Vol.56, 468~473, 2007
- Mass spectormetry based proteomic analysis of human stem cells: a brief review, Experimental and Molecular Medicine, Vol.39, 690~695, 2007
- Wondonin, a novel compound, inhibits hypoxia-induced angiogenesis through hypoxia-inducible factor 1 alpha, FEBS LETTERS, Vol.581, 4977~4982, 2007
- Structual basis fr depletion of heat shock protein 90 client proteins by deguelin, JOURNAL OF THE NATIONAL CANCER INSTITUTE, Vol.99, 949~961, 2007
- Anisomycin protects cortical neurons from prolonged hypoxia with differential regulation of p38 and ERK, BRAIN RESEARCH, Vol.1149, 76~86, 2007
- Determination of proteins in infant milk formula by nano-high performance liquid chromatography-electorospray tandem mass spectrometry, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Vol.845, 69~73, 2007
- Effect of anisomycin on neuronal injury induced by delta-opioid receptor inactivation in cortical neurons, DRUG METABOLISM REVIEWS, Vol.38, 75~3, 2006
- Altered pharmacokinetics and hepatic uptake of TBuMA in ethynylestradio-induced cholestasis, ARCHIVES OF PHARMACAL RESEARCH, Vol.29, 323~327, 2006
- Pharmacokinetics of metformin in ethinylestradiol-induced cholestatic rats, DRUG METABOLISM REVIEWS, Vol.38, 72~3, 2006
- Mechanism for increased bioavailability of tacrine in fasted rats, JOURNAL OF PHARMACY AND PHARMACOLOGY, Vol.58, 643~649, 2006
- Mechanism of intestinal transport of an organic cation, tributylmethylammonium in Caco-2 cell monolayers, ARCHIVES OF PHARMACAL RESEARCH, Vol.29, 318~322, 2006
- Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-opioid receptor, STROKE, Vol.37,No.4, 1094~1099, 2006
- Effect of a new hepatoprotective agent, YH-439, on the hepatobiliary transport of organic cations (OCs), ARCHIVES OF PHARMACAL RESEARCH, 2005
- Advanced formulation and pharmacological activity of hydrogel of the titrated extract of C. Asiatica, ARCHIVES OF PHARMACAL RESEARCH, Vol.28, 502~508, 2005
- Mechanism of the stationary canalicular excretion of tributylmethyl ammonium in rats with a CCl4-induced acute hepatic injury, JOURNAL OF PHARMACEUTICAL SCIENCES, Vol.94, 317~326, 2005
- Profiling of urinary proteins by nano-high performance liquid chromatography/tandem mass spectrometry, JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, Vol.28, 805~822, 2005
- Chronic hypoxia-induced upregulation of lactate dehydrogenase (LDH) activity is associated with increased LDH-1 protein expression & increases in glycolytic flux in cultured hypoxic neurons, FASEB JOURNAL, 184, A211, 2004
- Effect of protein kinases on lactate dehydrogenase activity in cortical neurons during hypoxia, BRAIN RESEARCH, Vol.36, 343~353, 2004
- Antioxidant properties of heat-treated Hibiscus syriacus, BIOLOGY BULLETIN, Vol.30, 15~16, 2003
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Books펼치기
- 약학용어집, 신일북스, 2008
- 생명의학 기초실험, 동인사, 2008
- 최신의과학용어사전, 녹십자, 2006
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Book Chapters
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Patents펼치기
- RPN1의 발현 또는 활성 억제제를 유효성분으로 포함하는 방사선 민감성 증진용 약학 조성물, 2024
- 프로포폴 및 리도카인을 유효성분으로 포함하는 유방암 예방 또는 치료용 약학 조성물, 2023
- Biomarker for diagnosing pancreatic cancer comprising asprosin and use thereof, 2023
- DDR1 저해제 및 항암제를 유효성분으로 포함하는 췌장암 예방 또는 치료용 약학 조성물, 2023
- 급성 췌장염 중증도 진단용 정보 제공 방법, 2022
- 암의 예방 또는 치료용 조성물, 2022
- 13C 또는 2H 동위원소로 표지된 글라이신을 유효성분으로 포함하는 간암 진단용 조성물, 2022
- 암의 예방 또는 치료용 조성물, 2022
- 췌장암 예방 또는 치료용 조성물, 2022
- 아스프로신을 포함하는 췌장암 진단용 바이오마커 및 이의 인용, 2022
- 퀴놀린 유도체 및 ALK와 변이된 ALK의 저해제로서의 용도(Quinoline Derivatives and Their Use as ALK and ALK L1196M Inhibitors), 2021
- 췌장암의 예방 또는 치료용 조성물, 2021
- 13C 또는 2H 동위원소로 표지된 글라이신을 유효성분으로 포함하는 간암 진단용 조성물, 2021
- 아스프로신을 포함하는 췌장암 진단용 바이오마커 및 이의 인용, 2021
- 한인진 추출물을 유효성분으로 포함하는 간암 예방 또는 치료용 조성물(Composition for preventing or treating liver cancer comprising Artemisia iwayomogi Kitamura extract), 2021
- 급성 췌장염 중증도 진단용 정보 제공 방법, 2021
- 아스프로신을 포함하는 췌장암 진단용 바이오마커 및 이의 이용, 2020
- 13C 또는 2H 동위원소로 표지된 글라이신을 유효성분으로 포함하는 간암 진단용 조성물, 2020
- 신규한 피롤로[2,3-d]피리미딘-4-온 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물(NOVEL PYRROLO[2,3-d]PYRIMIDIN-4-ONE DERIVATIVES AND COMPOSITIONS FOR PREVENTING OR TREATING CANCER CONTAIN, 2020
- 췌장암 예방 또는 치료용 조성물, 2020
- PI3KC2γ를 표적으로 하는 염증 질환 진단 및 치료용 조성물(Composition for diagnosing or treating inflammatory diseases tageting PI3KC2γ), 2020
- MMP-10 또는 이를 코딩하는 유전자의 발현을 억제하는 제제를 포함하는 암 전이 억제용 조성물(Composition for suppressing cancer metastasis comprising suppressor of MMP-10 or gene encoding the same), 2020
- 한인진 추출물을 유효성분으로 포함하는 간암 예방 또는 치료용 조성물, 2019
- 간질환 예방 또는 치료용 펩타이드 및 이를 유효성분으로 포함하는 조성물, 2019
- 창이자 추출물의 분획물을 포함하는 간암 예방 또는 치료용 조성물, 2019
- PI3-키나제 저해제 및 독소루비신의 복합조성물을 포함하는 항암용 약학조성물 및 이의 제조방법, 2018
- PI3KC2γ를 표적으로 하는 염증 질환 진단 및 치료용 조성물, 2018
- 신규한 피롤로[2,3-d]피리미딘-4-온 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물, 2018
- 췌장암 진단 또는 치료용 조성물, 2018
- 인진호 잎 추출물을 유효성분으로 함유하는 간암 예방 또는 치료용 조성물, 2018
- MMP-10 또는 이를 코딩하는 유전자의 발현을 억제하는 제제를 포함하는 암 전이 억제용 조성물, 2018
- 췌장암의 예방 또는 치료용 조성물, 2018
- 간암 예방 또는 치료용 조성물, 2018
- RAS-GTP 타겟 항체 (RT11-i) 및 젬시타빈을 유효성분으로 함유하는 췌장암의 예방 또는 치료용 조성물, 2018
- 퀴놀린 유도체 및 ALK와 변이된 ALK의 저해제로서의 용도, 2017
- PI3-키나제 저해제 및 독소루비신의 복합조성물을 포함하는 항암용 약학 조성물 및 이의 제조방법, 2017
- PI3K 및 mTOR 저해제를 유효성분으로 포함하는 염증성 질환의 예방 또는 치료용 약학적 조성물, 2017
- ANGPTL-4 항체를 유효성분으로 포함하는 염증성 질환의 예방 또는 치료용 약학적 조성물, 2017
- 이미다조피리딘 유도체를 유효성분으로 포함하는 암 전이 억제용 조성물, 2016
- PI3K 저해활성을 갖는 이미다조피리딘 유도체를 유효성분으로 포함하는 관절염의 예방 또는 치료용 조성물, 2016
- 간질환 예방 또는 치료용 펩타이드 및 이를 유효성분으로 포함하는 조성물, 2016
- 소라페닙 및 멜라토닌을 유효성분으로 포함하는 췌장암의 예방 또는 치료용 조성물(Composition for preventing or treating pancreatic cancer comprising sorafenib and melatonin), 2016
- 췌장염 진단용 바이오 마커 조성물, 2015
- 아자인돌 유도체 화합물, 이를 포함하는 TRK 저해제 조성물 및 TRK와 관련된 질환의 예방 및 치료용 약학 조성물, 2015
- 소라페닙 및 이미다조피리딘 유도체를 유효성분으로 함유하는 췌장암의 예방 또는 치료용 조성물, 2014
- 백합나무 추출물을 함유하는 만성 골수성 백혈병 치료용약학적 조성물, 2014
- LHP-cRGD를 유효성분으로 포함하는 간경화 예방 또는 치료용 조성물, 2014
- 이미다조피리딘 유도체, 이를 포함하는 PI3K 및/또는 mTOR 저해제용 약학 조성물 및 PI3K 및/또는 mTOR과 연관된 질환 치료용 약학 조성물, 2013
- 잔틴 유도체, 이를 포함하는 PI3K 저해제 조성물 및 PI3K와 연관된 질환 치료에 사용되는 조성물, 2013
- 아자인돌 화합물, 이를 포함하는 PI3K 저해제용 약학 조성물 및 PI3K와 연관된 질환 치료용 약학 조성물, 2013
- 지방줄기세포 유래 단백질 추출물을 안정화시킨 프로리포솜을 유효성분으로 포함하는 아토피성 피부염 치료 또는 예방용 조성물, 2012
- 줄기세포 배양액을 이용한 암세포 성장 저해 방법 (Inhibition of cancer cell proliferation using adult stem cells culture m, 2008
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Citation and Awards펼치기
- 우수논문 표창, 인하대학교 의료원, 2020.12.31.
- 우수논문 표창, 인하대학교 의료원, 2019.12.31.
- 우수논문 표창, 인하대학교 의료원, 2018.12.31.
- 국무총리 표창장, 국무총리 & 보건복지부, 2014.03.21.
- 우수연구상, 인하대병원, 2011.12.30.